1 Diabetes mellitus type 2 (T2DM) is more common with more than 90% diabetic patients suffering from it. Future research directions based on this review include the synergistic usage of various cinnamon derivatives in managing and/or preventing diabetes and possible other relevant chronic diseases.ĭiabetes mellitus (DM) is one of the most important and key public health issues which is affecting more than 400 million people globally. It was also found that the type and dosage of cinnamon as well as subject characteristics including drug interactions are likely to affect the response to cinnamon. The current review presents the outstanding ability of cinnamon derivatives to control diabetes by various pathways modulating insulin release and insulin receptor signaling.

However, the mechanism of action of active ingredients found in cinnamon remains unclear. Cinnamon has shown to improve all of these conditions in in vitro, animal, and/or human studies. These chemicals help in decreasing insulin resistance and can act against hyperglycemia and dyslipidemia, inflammation and oxidative stress, obesity, overweight, and abnormal glycation of proteins. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent extraction. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. Apart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources.

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